Gingerenone A

CAS No. 128700-97-0

Gingerenone A( AS-HK014 | AS HK014 | ASHK014 | Gingerenone A | Gingerenone-A )

Catalog No. M11170 CAS No. 128700-97-0

A dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gingerenone A
  • Note
    Research use only, not for human use.
  • Brief Description
    A dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells.
  • Description
    A dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells; induces apoptosis in cancer cells and suppresses tumor growth in vivo associated with relative phosphorylation levels of JAK2 and S6K1; suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AS-HK014 | AS HK014 | ASHK014 | Gingerenone A | Gingerenone-A
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    128700-97-0
  • Formula Weight
    356.418
  • Molecular Formula
    C21H24O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (280.58 mM)
  • SMILES
    O=C(/C=C/CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
  • Chemical Name
    4-Hepten-3-one, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Byun S, et al. J Biol Chem. 2015 Sep 25;290(39):23553-62. 2. Kim HJ, et al. J Cell Biochem. 2018 Jan;119(1):260-268. 3. Suk S, et al. Mol Nutr Food Res. 2017 Oct;61(10).
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